Drug interactions
Amifostine + Verapamil
Severity: Moderate
Amifostine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and verapamil adds to this effect. Severe hypotension may occur at chemotherapeutic amifostine doses.
What this interaction means in plain words
Amifostine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering.
What to do
At chemotherapeutic amifostine doses, withhold verapamil for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Verapamil?
MediHelp rates the interaction as moderate. Amifostine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and verapamil adds to this effect. Severe hypotension may occur at chemotherapeutic amifostine doses.
How serious is the interaction between Amifostine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At chemotherapeutic amifostine doses, withhold verapamil for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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