Drug interactions
dofetilide + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ dofetilide concentration → torsades risk.
Mechanism of action
P-gp/CYP interactions affecting clearance.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take dofetilide with verapamil?
The interaction is rated: Contraindicated. ↑ dofetilide concentration → torsades risk.
How serious is the interaction between dofetilide and verapamil?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dofetilide and verapamil managed?
Contraindicated.
Why do dofetilide and verapamil interact?
P-gp/CYP interactions affecting clearance.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.