Drug interactions
Lomitapide + Verapamil
Severity: Contraindicated
Lomitapide and Verapamil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and can raise lomitapide exposure several-fold. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling for lomitapide prohibits use with moderate and strong CYP3A4 inhibitors.
What this interaction means in plain words
Lomitapide and Verapamil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lomitapide belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated first-pass and hepatic metabolism of lomitapide, markedly increasing its plasma concentration.
What to do
Do not co-administer; choose a different antihypertensive or antianginal such as a non-CYP3A4-inhibiting agent. Monitor liver enzymes if lomitapide therapy is continued with an alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
- Alfentanil + Verapamil Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Verapamil?
MediHelp rates the interaction as contraindicated. Lomitapide and Verapamil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Verapamil is a moderate CYP3A4 inhibitor and can raise lomitapide exposure several-fold. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling for lomitapide prohibits use with moderate and strong CYP3A4 inhibitors.
How serious is the interaction between Lomitapide and Verapamil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose a different antihypertensive or antianginal such as a non-CYP3A4-inhibiting agent. Monitor liver enzymes if lomitapide therapy is continued with an alternative.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lonafarnib. The full list is on the Verapamil page.
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