Drug interactions
Amifostine + Ziprasidone
Severity: Moderate
Amifostine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and ziprasidone's alpha-adrenergic blockade can add to this effect. The result may be marked blood pressure drops or orthostatic symptoms.
What this interaction means in plain words
Amifostine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects via alpha-1 antagonism from ziprasidone and amifostine's own hypotensive action.
What to do
Monitor blood pressure before and during amifostine infusion, and ensure adequate hydration. Consider holding antihypertensives as labeling advises and review the need for ziprasidone timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Ziprasidone?
MediHelp rates the interaction as moderate. Amifostine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and ziprasidone's alpha-adrenergic blockade can add to this effect. The result may be marked blood pressure drops or orthostatic symptoms.
How serious is the interaction between Amifostine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion, and ensure adequate hydration. Consider holding antihypertensives as labeling advises and review the need for ziprasidone timing.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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