Drug reference
ziprasidone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Psychotic (atypical))
Mechanism of action
Acts as antagonist at dopamine D2 and serotonin type 1 and 2 (5HT1D, 5HT2A) receptors; acts as agonist at serotonin 5HT1A receptor; moderately inhibits reuptake of norepinephrine and serotonin; has alpha-blocking and antihistaminic activity
Common side effects
- Extrapyramidal symptoms
- Dizziness
- Somnolence
- Headache
- Nausea
Known interactions (10)
- amiodarone + ziprasidone Contraindicated
- citalopram + ziprasidone Contraindicated
- dronedarone + ziprasidone Contraindicated
- escitalopram + ziprasidone Contraindicated
- amisulpride + ziprasidone Major
- goserelin + ziprasidone Major
- indapamide + ziprasidone Major
- moxifloxacin + ziprasidone Major
- cabergoline + ziprasidone Moderate
- dopamine + ziprasidone Moderate
Related conditions
Frequently asked questions
What drug class is ziprasidone?
ziprasidone belongs to: Central Nervous System.
How does ziprasidone work?
Acts as antagonist at dopamine D2 and serotonin type 1 and 2 (5HT1D, 5HT2A) receptors; acts as agonist at serotonin 5HT1A receptor; moderately inhibits reuptake of norepinephrine and serotonin; has alpha-blocking and antihistaminic activity
What are the common side effects of ziprasidone?
Extrapyramidal symptoms, Dizziness, Somnolence, Headache, Nausea
Which drugs interact with ziprasidone?
amiodarone, citalopram, dronedarone, escitalopram, amisulpride, goserelin, indapamide, moxifloxacin, cabergoline, dopamine
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