Drug interactions
Chloroquine + Ziprasidone
Severity: Contraindicated
Chloroquine and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is known for QT prolongation and its labeling advises against use with other QT-prolonging drugs. Adding chloroquine increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Chloroquine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium channels leading to delayed repolarization.
What to do
Avoid the combination and use a different antipsychotic or antimalarial. Ziprasidone labeling lists other QT-prolonging drugs as contraindicated.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
- Clarithromycin + Ziprasidone Contraindicated
Frequently asked questions
Can I take Chloroquine with Ziprasidone?
MediHelp rates the interaction as contraindicated. Chloroquine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known for QT prolongation and its labeling advises against use with other QT-prolonging drugs. Adding chloroquine increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Chloroquine and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different antipsychotic or antimalarial. Ziprasidone labeling lists other QT-prolonging drugs as contraindicated.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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