Drug interactions
Amikacin + Cyclosporin
Severity: Major
Amikacin and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and aminoglycosides given with cyclosporine increase the risk of acute kidney injury. Ototoxicity risk may also rise as aminoglycoside clearance falls.
What this interaction means in plain words
Amikacin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with cyclosporine-induced renal vasoconstriction compounding aminoglycoside tubular toxicity.
What to do
Avoid if an alternative antibiotic is suitable. If needed, monitor serum creatinine and amikacin and cyclosporine levels frequently and keep aminoglycoside courses short.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Cyclosporin?
MediHelp rates the interaction as major. Amikacin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and aminoglycosides given with cyclosporine increase the risk of acute kidney injury. Ototoxicity risk may also rise as aminoglycoside clearance falls.
How serious is the interaction between Amikacin and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic is suitable. If needed, monitor serum creatinine and amikacin and cyclosporine levels frequently and keep aminoglycoside courses short.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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