Drug interactions
Amikacin + Flurbiprofen
Severity: Moderate
Amikacin and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, raising amikacin levels, an effect best described in preterm neonates treated with indomethacin or ibuprofen. In adults, NSAID-induced renal impairment may also increase aminoglycoside nephrotoxicity and ototoxicity.
What this interaction means in plain words
Amikacin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins lowers renal blood flow and glomerular filtration, reducing aminoglycoside elimination.
What to do
Monitor amikacin serum concentrations and renal function when used together. Avoid in patients with renal impairment or dehydration where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Flurbiprofen?
MediHelp rates the interaction as moderate. Amikacin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, raising amikacin levels, an effect best described in preterm neonates treated with indomethacin or ibuprofen. In adults, NSAID-induced renal impairment may also increase aminoglycoside nephrotoxicity and ototoxicity.
How serious is the interaction between Amikacin and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and renal function when used together. Avoid in patients with renal impairment or dehydration where possible.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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