Drug interactions
Amikacin + Ibuprofen
Severity: Moderate
Amikacin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce renal clearance of amikacin, raising its serum levels and the risk of nephrotoxicity and ototoxicity. This has been described mainly in preterm neonates treated for patent ductus arteriosus.
What this interaction means in plain words
Amikacin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration decreases aminoglycoside elimination.
What to do
Monitor amikacin serum concentrations and renal function, and adjust the dose or interval accordingly. Take particular care in neonates and patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ibuprofen?
MediHelp rates the interaction as moderate. Amikacin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce renal clearance of amikacin, raising its serum levels and the risk of nephrotoxicity and ototoxicity. This has been described mainly in preterm neonates treated for patent ductus arteriosus.
How serious is the interaction between Amikacin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and renal function, and adjust the dose or interval accordingly. Take particular care in neonates and patients with renal impairment.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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