Drug interactions
Amikacin + Meclofenamic acid
Severity: Moderate
Amikacin and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-dependent perfusion and can raise aminoglycoside concentrations, a effect best documented in preterm infants given indomethacin or ibuprofen. In adults the effect is less well established, but nephrotoxicity is a concern.
What this interaction means in plain words
Amikacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Reduced renal clearance of amikacin due to NSAID inhibition of prostaglandin-mediated renal blood flow.
What to do
Monitor amikacin serum levels and renal function when co-administered. Avoid NSAIDs in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Meclofenamic acid?
MediHelp rates the interaction as moderate. Amikacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin-dependent perfusion and can raise aminoglycoside concentrations, a effect best documented in preterm infants given indomethacin or ibuprofen. In adults the effect is less well established, but nephrotoxicity is a concern.
How serious is the interaction between Amikacin and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum levels and renal function when co-administered. Avoid NSAIDs in patients with renal impairment or dehydration.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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