Drug interactions
Amikacin + Meloxicam
Severity: Moderate
Amikacin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-dependent perfusion and may raise aminoglycoside concentrations, mainly documented in preterm neonates treated with other NSAIDs. In adults, the combined nephrotoxic potential is the main concern.
What this interaction means in plain words
Amikacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration decreases aminoglycoside clearance and adds nephrotoxic stress.
What to do
Monitor serum creatinine and amikacin trough levels during concurrent use. Avoid in neonates and in patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Meloxicam?
MediHelp rates the interaction as moderate. Amikacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin-dependent perfusion and may raise aminoglycoside concentrations, mainly documented in preterm neonates treated with other NSAIDs. In adults, the combined nephrotoxic potential is the main concern.
How serious is the interaction between Amikacin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels during concurrent use. Avoid in neonates and in patients with renal impairment where possible.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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