Drug interactions
Amikacin + Naproxen
Severity: Moderate
Amikacin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of aminoglycosides, which has been mainly described in preterm infants receiving indomethacin or ibuprofen. In adults the effect is less defined, but both drugs are potentially nephrotoxic.
What this interaction means in plain words
Amikacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins lowers glomerular filtration and aminoglycoside clearance, increasing exposure and nephrotoxic potential.
What to do
Monitor serum creatinine and amikacin trough levels when the two are given together. Avoid the combination in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Naproxen?
MediHelp rates the interaction as moderate. Amikacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of aminoglycosides, which has been mainly described in preterm infants receiving indomethacin or ibuprofen. In adults the effect is less defined, but both drugs are potentially nephrotoxic.
How serious is the interaction between Amikacin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels when the two are given together. Avoid the combination in patients with renal impairment or dehydration.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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