Drug interactions
Amikacin + Sulphasalazine
Severity: Minor
Amikacin and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The suggestion is that sulfasalazine reduces renal clearance of amikacin, mainly in preterm infants. This is poorly documented and is not an established interaction with sulfasalazine.
What this interaction means in plain words
Amikacin and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Not established; possible reduced renal clearance of the aminoglycoside.
What to do
Monitor amikacin serum concentrations and renal function as is standard practice. Pay particular attention in neonates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Sulphasalazine?
MediHelp rates the interaction as minor. Amikacin and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The suggestion is that sulfasalazine reduces renal clearance of amikacin, mainly in preterm infants. This is poorly documented and is not an established interaction with sulfasalazine.
How serious is the interaction between Amikacin and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and renal function as is standard practice. Pay particular attention in neonates.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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