Drug reference
amlodipine-hydrochlorothiazide-valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Amlodipine: Calcium channer blocker; blocks contractile effects of calcium on cardiac and vascular smooth muscle cells. Valsartan: Angiotensin receptor blocker; blocks vasoconstriction and sodium retaining effects of angiotensin II on cardiac. Hydrochlorothiazide: Thiazide diuretic; directly promotes the excretion of sodium and chloride.
Common side effects
- Anorexia
- Edema
- Headache
- Fatigue
- Hyperkalemia
- Hypotension
- Palpitation
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to valsartan, amlodipine, sulfonamide drugs, or other ingredients Pregnancy (2nd and 3rd trimesters): Significant risk of fetal/neonatal morbidity and mortality Anuria Coadministration with aliskiren in patients with diabetes
Known interactions (2)
Related conditions
Frequently asked questions
What drug class is amlodipine-hydrochlorothiazide-valsartan?
amlodipine-hydrochlorothiazide-valsartan belongs to: Cardiovascular.
How does amlodipine-hydrochlorothiazide-valsartan work?
Amlodipine: Calcium channer blocker; blocks contractile effects of calcium on cardiac and vascular smooth muscle cells. Valsartan: Angiotensin receptor blocker; blocks vasoconstriction and sodium retaining effects of angiotensin II on cardiac. Hydrochlorothiazide: Thiazide diuretic; directly promotes the excretion of sodium and chloride.
What are the common side effects of amlodipine-hydrochlorothiazide-valsartan?
Anorexia, Edema, Headache, Fatigue, Hyperkalemia, Hypotension, Palpitation
Which drugs interact with amlodipine-hydrochlorothiazide-valsartan?
dantrolene, isocarboxazid
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