Drug interactions
Amiloride + Azilsartan-chlorthalidone
Severity: Moderate
Amiloride and Azilsartan-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is a potassium-sparing diuretic and azilsartan reduces aldosterone effects, both of which raise potassium, whereas chlorthalidone lowers it. Net potassium may be unpredictable, and hyperkalemia is possible especially with renal impairment or diabetes.
What this interaction means in plain words
Amiloride and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Azilsartan-chlorthalidone belongs to Cardiovascular.
Why it happens
Opposing effects on potassium: ENaC blockade and angiotensin receptor blockade retain potassium while thiazide-like diuresis wastes it.
What to do
Check serum potassium and creatinine within the first weeks and periodically thereafter. Adjust or stop amiloride if hyperkalemia develops, particularly in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Azilsartan-chlorthalidone?
MediHelp rates the interaction as moderate. Amiloride and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiloride is a potassium-sparing diuretic and azilsartan reduces aldosterone effects, both of which raise potassium, whereas chlorthalidone lowers it. Net potassium may be unpredictable, and hyperkalemia is possible especially with renal impairment or diabetes.
How serious is the interaction between Amiloride and Azilsartan-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within the first weeks and periodically thereafter. Adjust or stop amiloride if hyperkalemia develops, particularly in renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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