Drug interactions
Azilsartan-chlorthalidone + Sparsentan
Severity: Contraindicated
Azilsartan-chlorthalidone and Sparsentan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azilsartan-chlorthalidone belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Additive angiotensin II type 1 receptor blockade with duplicated pharmacodynamic effects.
What to do
Do not coadminister; discontinue the ARB before starting sparsentan and monitor blood pressure, potassium and renal function.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan + Sparsentan Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sparsentan?
MediHelp rates the interaction as contraindicated. Azilsartan-chlorthalidone and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; discontinue the ARB before starting sparsentan and monitor blood pressure, potassium and renal function.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Aceclofenac, Aldesleukin. The full list is on the Azilsartan-chlorthalidone page.
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