Drug interactions
Amiloride + Chlorothiazide
Severity: Minor
Amiloride and Chlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride and thiazide diuretics are commonly combined deliberately, because amiloride offsets thiazide-induced potassium and magnesium loss and adds diuretic effect. Hyperkalemia can still occur, especially in renal impairment, and hyponatremia or volume depletion may develop.
What this interaction means in plain words
Amiloride and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Amiloride blocks ENaC in the collecting duct and conserves potassium, while chlorothiazide inhibits the sodium-chloride cotransporter and promotes potassium loss, so the effects are complementary.
What to do
Monitor serum potassium, sodium and renal function periodically, particularly after dose changes. Reassess if renal function declines or other potassium-raising drugs are added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Amiloride with Chlorothiazide?
MediHelp rates the interaction as minor. Amiloride and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride and thiazide diuretics are commonly combined deliberately, because amiloride offsets thiazide-induced potassium and magnesium loss and adds diuretic effect. Hyperkalemia can still occur, especially in renal impairment, and hyponatremia or volume depletion may develop.
How serious is the interaction between Amiloride and Chlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and renal function periodically, particularly after dose changes. Reassess if renal function declines or other potassium-raising drugs are added.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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