Drug interactions
Amiloride + Etodolac
Severity: Moderate
Amiloride and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce renal potassium excretion and renal perfusion, which adds to the potassium-retaining effect of amiloride. This may cause hyperkalemia and acute kidney injury, particularly in older patients or those with renal disease.
What this interaction means in plain words
Amiloride and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID prostaglandin inhibition reduces renin, aldosterone and renal potassium excretion, adding to amiloride sodium channel blockade.
What to do
Monitor serum potassium and creatinine after starting and periodically during use. Avoid in patients with renal impairment or other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiloride and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Etodolac?
MediHelp rates the interaction as moderate. Amiloride and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce renal potassium excretion and renal perfusion, which adds to the potassium-retaining effect of amiloride. This may cause hyperkalemia and acute kidney injury, particularly in older patients or those with renal disease.
How serious is the interaction between Amiloride and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine after starting and periodically during use. Avoid in patients with renal impairment or other potassium-raising drugs.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
