Drug interactions
Amiloride + Levodopa
Severity: Minor
Amiloride and Levodopa: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, which may be amplified by amiloride. Patients may experience dizziness or falls, especially early in treatment.
What this interaction means in plain words
Amiloride and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering from dopaminergic vasodilation and diuretic-related volume reduction.
What to do
Monitor sitting and standing blood pressure after starting or increasing levodopa. Lower the diuretic dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Amiloride with Levodopa?
MediHelp rates the interaction as minor. Amiloride and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levodopa can cause orthostatic hypotension, which may be amplified by amiloride. Patients may experience dizziness or falls, especially early in treatment.
How serious is the interaction between Amiloride and Levodopa?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure after starting or increasing levodopa. Lower the diuretic dose if symptomatic hypotension develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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