Drug interactions
Amiloride + Oxaprozin
Severity: Major
Amiloride and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as oxaprozin can increase serum potassium and reduce renal function, which compounds the potassium-retaining effect of amiloride. Severe hyperkalemia and acute kidney injury may result, especially in older or renally impaired patients.
What this interaction means in plain words
Amiloride and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID suppression of renal prostaglandins, renin and aldosterone reduces potassium excretion, adding to amiloride's blockade of distal sodium channels.
What to do
Avoid the combination in patients with renal impairment or diabetes, and prefer another analgesic. If used, check potassium and creatinine early and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Oxaprozin?
MediHelp rates the interaction as major. Amiloride and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as oxaprozin can increase serum potassium and reduce renal function, which compounds the potassium-retaining effect of amiloride. Severe hyperkalemia and acute kidney injury may result, especially in older or renally impaired patients.
How serious is the interaction between Amiloride and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with renal impairment or diabetes, and prefer another analgesic. If used, check potassium and creatinine early and periodically.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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