Drug interactions
Ketorolac + Oxaprozin
Severity: Contraindicated
Ketorolac and Oxaprozin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent oxaprozin and ketorolac adds gastrointestinal, renal and bleeding risk with no analgesic advantage. Ketorolac labeling prohibits use with other NSAIDs.
What this interaction means in plain words
Ketorolac and Oxaprozin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketorolac belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Do not combine; use a single NSAID. Because oxaprozin has a long half-life, allow for its persistence when switching to ketorolac.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
- Amiloride + Oxaprozin Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Oxaprozin?
MediHelp rates the interaction as contraindicated. Ketorolac and Oxaprozin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent oxaprozin and ketorolac adds gastrointestinal, renal and bleeding risk with no analgesic advantage. Ketorolac labeling prohibits use with other NSAIDs.
How serious is the interaction between Ketorolac and Oxaprozin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single NSAID. Because oxaprozin has a long half-life, allow for its persistence when switching to ketorolac.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Aceclofenac, Acemetacin. The full list is on the Oxaprozin page.
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