Drug interactions
Amiloride + Quinidine
Severity: Moderate
Amiloride and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride can cause hyperkalemia, which alters quinidine's effect on cardiac conduction. Disturbed potassium may also increase proarrhythmic risk, especially in patients with ventricular arrhythmias.
What this interaction means in plain words
Amiloride and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Pharmacodynamic: amiloride-related potassium changes modify quinidine's electrophysiological effects; no direct pharmacokinetic mechanism is established.
What to do
Monitor serum potassium and ECG during combined use. Correct electrolyte disturbances promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Quinidine?
MediHelp rates the interaction as moderate. Amiloride and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiloride can cause hyperkalemia, which alters quinidine's effect on cardiac conduction. Disturbed potassium may also increase proarrhythmic risk, especially in patients with ventricular arrhythmias.
How serious is the interaction between Amiloride and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during combined use. Correct electrolyte disturbances promptly.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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