Drug interactions
Amiloride + Treprostinil
Severity: Minor
Amiloride and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and can lower blood pressure. Given together with a diuretic such as amiloride, the blood pressure-lowering effect may be additive, leading to hypotension or dizziness.
What this interaction means in plain words
Amiloride and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect on blood pressure through vasodilation and volume reduction.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Amiloride with Treprostinil?
MediHelp rates the interaction as minor. Amiloride and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a potent vasodilator and can lower blood pressure. Given together with a diuretic such as amiloride, the blood pressure-lowering effect may be additive, leading to hypotension or dizziness.
How serious is the interaction between Amiloride and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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