Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Treprostinil
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator, so adding it to antihypertensives can cause additive blood pressure lowering. Symptomatic hypotension is possible, especially at initiation or dose increases.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure when starting or titrating treprostinil and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Treprostinil
- Aldesleukin + Treprostinil Moderate
- Alfuzosin + Treprostinil Moderate
- Amlodipine-atorvastatin + Treprostinil Moderate
- Amlodipine-benazepril + Treprostinil Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Treprostinil Moderate
- Amlodipine-olmesartan + Treprostinil Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Treprostinil?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a vasodilator, so adding it to antihypertensives can cause additive blood pressure lowering. Symptomatic hypotension is possible, especially at initiation or dose increases.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or titrating treprostinil and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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