Drug interactions
Amlodipine-atorvastatin + Treprostinil
Severity: Moderate
Amlodipine-atorvastatin and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with antihypertensives such as amlodipine may cause additive hypotension. Symptoms include dizziness and syncope.
What this interaction means in plain words
Amlodipine-atorvastatin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor agonism and calcium channel blockade.
What to do
Monitor blood pressure when starting or titrating treprostinil and reduce amlodipine if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Treprostinil
Frequently asked questions
Can I take Amlodipine-atorvastatin with Treprostinil?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with antihypertensives such as amlodipine may cause additive hypotension. Symptoms include dizziness and syncope.
How serious is the interaction between Amlodipine-atorvastatin and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or titrating treprostinil and reduce amlodipine if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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