Drug interactions
Amiloride + Trilaciclib
Severity: Moderate
Amiloride and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal organic cation and MATE transporters involved in amiloride secretion. Amiloride exposure may rise, increasing the risk of hyperkalemia.
What this interaction means in plain words
Amiloride and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which may reduce renal tubular secretion of amiloride.
What to do
Check serum potassium around trilaciclib administration. Consider holding or reducing amiloride if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Amiloride with Trilaciclib?
MediHelp rates the interaction as moderate. Amiloride and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits renal organic cation and MATE transporters involved in amiloride secretion. Amiloride exposure may rise, increasing the risk of hyperkalemia.
How serious is the interaction between Amiloride and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium around trilaciclib administration. Consider holding or reducing amiloride if potassium rises.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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