Drug interactions
Dalfampridine + Trilaciclib
Severity: Major
Dalfampridine and Trilaciclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dalfampridine is eliminated largely by active renal secretion through OCT2. Trilaciclib inhibits renal transporters, which may raise dalfampridine levels and increase the risk of seizures, a concentration-dependent toxicity.
What this interaction means in plain words
Dalfampridine and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalfampridine belongs to Central Nervous System; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits OCT2 and MATE transporters, reducing renal secretion of dalfampridine.
What to do
Avoid the combination where possible, and weigh the benefit of trilaciclib against seizure risk. If used together, monitor for neurological symptoms, especially in patients with renal impairment or seizure history.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalfampridine
- Alogliptin-metformin + Dalfampridine Moderate
- Canagliflozin-metformin + Dalfampridine Moderate
- Dalfampridine + Dapagliflozin-metformin Moderate
- Dalfampridine + Dolutegravir Moderate
- Dalfampridine + Empagliflozin-metformin Moderate
- Dalfampridine + Glipizide-metformin Moderate
Other interactions of Trilaciclib
Frequently asked questions
Can I take Dalfampridine with Trilaciclib?
MediHelp rates the interaction as major. Dalfampridine and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dalfampridine is eliminated largely by active renal secretion through OCT2. Trilaciclib inhibits renal transporters, which may raise dalfampridine levels and increase the risk of seizures, a concentration-dependent toxicity.
How serious is the interaction between Dalfampridine and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and weigh the benefit of trilaciclib against seizure risk. If used together, monitor for neurological symptoms, especially in patients with renal impairment or seizure history.
What other medicines interact with Dalfampridine?
MediHelp also lists interactions of Dalfampridine with, for example, Alogliptin-metformin, Canagliflozin-metformin, Dapagliflozin-metformin. The full list is on the Dalfampridine page.
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