Drug interactions
Aminohippurate + Candesartan-hydrochlorothiazide
Severity: Minor
Aminohippurate and Candesartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate is used as a diagnostic agent to measure effective renal plasma flow and is secreted by organic anion transporters in the proximal tubule. Hydrochlorothiazide competes for this secretion and may reduce aminohippurate clearance, which could lead to an overestimate of its plasma levels and an underestimate of renal plasma flow.
What this interaction means in plain words
Aminohippurate and Candesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
Consider the effect when interpreting renal plasma flow measurements; the diuretic can be held before testing if clinically appropriate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aminohippurate with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aminohippurate and Candesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminohippurate is used as a diagnostic agent to measure effective renal plasma flow and is secreted by organic anion transporters in the proximal tubule. Hydrochlorothiazide competes for this secretion and may reduce aminohippurate clearance, which could lead to an overestimate of its plasma levels and an underestimate of renal plasma flow.
How serious is the interaction between Aminohippurate and Candesartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider the effect when interpreting renal plasma flow measurements; the diuretic can be held before testing if clinically appropriate.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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