Drug reference
candesartan-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Candesartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. HCT: inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
Common side effects
- Upper respiratory tract infection
- Dizziness
- Headache
- Back pain
- Flu-like syndrome
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to candesartan, hydrochlorothiazide, or sulfonamides Pregnancy (2nd and 3rd trimesters): Significant risk of fetal/neonatal morbidity and mortality Gout Refractory hypercalcemia Refractory hypokalemia Severe hepatic impairment and/or cholestasis Do not coadministe…
Related conditions
Frequently asked questions
What drug class is candesartan-hydrochlorothiazide?
candesartan-hydrochlorothiazide belongs to: Cardiovascular.
How does candesartan-hydrochlorothiazide work?
Candesartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. HCT: inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
What are the common side effects of candesartan-hydrochlorothiazide?
Upper respiratory tract infection, Dizziness, Headache, Back pain, Flu-like syndrome
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