Drug interactions
Aminohippurate + Captopril-hydrochlorothiazide
Severity: Minor
Aminohippurate and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and aminohippurate are both organic anions secreted by proximal tubule transporters. Competition for secretion may reduce aminohippurate clearance and distort renal plasma flow measurements that depend on it.
What this interaction means in plain words
Aminohippurate and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion.
What to do
If aminohippurate clearance is used to estimate renal plasma flow, interpret the result with the thiazide in mind or consider holding the diuretic per the testing protocol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aminohippurate and Captopril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aminohippurate with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aminohippurate and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and aminohippurate are both organic anions secreted by proximal tubule transporters. Competition for secretion may reduce aminohippurate clearance and distort renal plasma flow measurements that depend on it.
How serious is the interaction between Aminohippurate and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If aminohippurate clearance is used to estimate renal plasma flow, interpret the result with the thiazide in mind or consider holding the diuretic per the testing protocol.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
