Drug interactions
Aminohippurate + Cefepime
Severity: Minor
Aminohippurate and Cefepime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions secreted by renal tubular transporters, so cefepime may compete with aminohippurate for secretion. This could slightly alter PAH clearance used to estimate renal plasma flow, with no therapeutic consequence.
What this interaction means in plain words
Aminohippurate and Cefepime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transporter secretion.
What to do
Be aware that cefepime may confound PAH clearance measurement; interpret renal plasma flow results accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
Frequently asked questions
Can I take Aminohippurate with Cefepime?
MediHelp rates the interaction as minor. Aminohippurate and Cefepime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions secreted by renal tubular transporters, so cefepime may compete with aminohippurate for secretion. This could slightly alter PAH clearance used to estimate renal plasma flow, with no therapeutic consequence.
How serious is the interaction between Aminohippurate and Cefepime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that cefepime may confound PAH clearance measurement; interpret renal plasma flow results accordingly.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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