Drug interactions
Aminohippurate + Diclofenac
Severity: Minor
Aminohippurate and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate is a diagnostic agent used to measure renal plasma flow, and NSAIDs compete for organic anion tubular secretion. Diclofenac may therefore slightly reduce aminohippurate clearance and bias the test result.
What this interaction means in plain words
Aminohippurate and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport (OAT) secretion.
What to do
Interpret renal plasma flow measurements with awareness of recent NSAID use; hold the NSAID before testing if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Aminohippurate with Diclofenac?
MediHelp rates the interaction as minor. Aminohippurate and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminohippurate is a diagnostic agent used to measure renal plasma flow, and NSAIDs compete for organic anion tubular secretion. Diclofenac may therefore slightly reduce aminohippurate clearance and bias the test result.
How serious is the interaction between Aminohippurate and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret renal plasma flow measurements with awareness of recent NSAID use; hold the NSAID before testing if feasible.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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