Drug interactions
Aminohippurate + Diflunisal
Severity: Minor
Aminohippurate and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate is secreted by renal organic anion transporters to measure renal plasma flow. Diflunisal competes for the same pathway, which may alter the test result.
What this interaction means in plain words
Aminohippurate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
Interpret PAH clearance results with awareness of NSAID use. Consider withholding diflunisal before the test if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Aminohippurate with Diflunisal?
MediHelp rates the interaction as minor. Aminohippurate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminohippurate is secreted by renal organic anion transporters to measure renal plasma flow. Diflunisal competes for the same pathway, which may alter the test result.
How serious is the interaction between Aminohippurate and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret PAH clearance results with awareness of NSAID use. Consider withholding diflunisal before the test if feasible.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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