Drug interactions
Aminohippurate + Enalapril-hydrochlorothiazide
Severity: Minor
Aminohippurate and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide competes with aminohippurate for renal tubular secretion, which can reduce aminohippurate clearance. This may distort renal plasma flow measurements made with aminohippurate.
What this interaction means in plain words
Aminohippurate and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporters in the proximal renal tubule.
What to do
Be aware of this when interpreting renal plasma flow tests; consider holding the thiazide before testing if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aminohippurate with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aminohippurate and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide competes with aminohippurate for renal tubular secretion, which can reduce aminohippurate clearance. This may distort renal plasma flow measurements made with aminohippurate.
How serious is the interaction between Aminohippurate and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of this when interpreting renal plasma flow tests; consider holding the thiazide before testing if feasible.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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