Drug reference
enalapril-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Enalapril: Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism. Hydrochlorothiazide: Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules.
Common side effects
- Rash
- Dizziness
- Headache
- Chest pain
- Hypotension
- Cough
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to ACE inhibitors, thiazides or sulfonamides ACE-inibitor induced angioedema, hereditary or idiopathic angioedema Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of swit…
Related conditions
Frequently asked questions
What drug class is enalapril-hydrochlorothiazide?
enalapril-hydrochlorothiazide belongs to: Cardiovascular.
How does enalapril-hydrochlorothiazide work?
Enalapril: Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism. Hydrochlorothiazide: Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules.
What are the common side effects of enalapril-hydrochlorothiazide?
Rash, Dizziness, Headache, Chest pain, Hypotension, Cough
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