Drug interactions
Dofetilide + Enalapril-hydrochlorothiazide
Severity: Contraindicated
Dofetilide and Enalapril-hydrochlorothiazide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can increase dofetilide exposure and cause hypokalemia or hypomagnesemia, which favors QT prolongation. This raises the risk of torsades de pointes.
What this interaction means in plain words
Dofetilide and Enalapril-hydrochlorothiazide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides reduce renal clearance of dofetilide and deplete potassium and magnesium, adding to QT prolongation.
What to do
Avoid per dofetilide labeling; choose a non-thiazide antihypertensive and, if dofetilide is essential, keep potassium and magnesium normal with ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
- Azathioprine + Enalapril-hydrochlorothiazide Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as contraindicated. Dofetilide and Enalapril-hydrochlorothiazide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can increase dofetilide exposure and cause hypokalemia or hypomagnesemia, which favors QT prolongation. This raises the risk of torsades de pointes.
How serious is the interaction between Dofetilide and Enalapril-hydrochlorothiazide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid per dofetilide labeling; choose a non-thiazide antihypertensive and, if dofetilide is essential, keep potassium and magnesium normal with ECG monitoring.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril-hydrochlorothiazide page.
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