Drug interactions
Aminohippurate + Etodolac
Severity: Minor
Aminohippurate and Etodolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both compounds are organic anions handled by renal tubular secretion, so etodolac may compete with aminohippurate and slightly reduce its clearance. Aminohippurate is used diagnostically to measure renal plasma flow, so the practical effect is possible distortion of test results.
What this interaction means in plain words
Aminohippurate and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporters in renal tubular secretion.
What to do
Be aware that NSAIDs may affect PAH clearance measurements; consider withholding etodolac before renal plasma flow testing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Aminohippurate with Etodolac?
MediHelp rates the interaction as minor. Aminohippurate and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both compounds are organic anions handled by renal tubular secretion, so etodolac may compete with aminohippurate and slightly reduce its clearance. Aminohippurate is used diagnostically to measure renal plasma flow, so the practical effect is possible distortion of test results.
How serious is the interaction between Aminohippurate and Etodolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that NSAIDs may affect PAH clearance measurements; consider withholding etodolac before renal plasma flow testing.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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