Drug interactions
Aminohippurate + Indomethacin
Severity: Minor
Aminohippurate and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin competes with aminohippurate for renal tubular secretion by organic anion transporters. This can lower aminohippurate clearance and bias renal plasma flow measurements.
What this interaction means in plain words
Aminohippurate and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competitive inhibition of organic anion transporter-mediated tubular secretion.
What to do
Consider holding indomethacin before renal plasma flow testing, or interpret PAH clearance results accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Aminohippurate with Indomethacin?
MediHelp rates the interaction as minor. Aminohippurate and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin competes with aminohippurate for renal tubular secretion by organic anion transporters. This can lower aminohippurate clearance and bias renal plasma flow measurements.
How serious is the interaction between Aminohippurate and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding indomethacin before renal plasma flow testing, or interpret PAH clearance results accordingly.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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