Drug interactions
Aminohippurate + Probenecid
Severity: Moderate
Aminohippurate and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid blocks the renal tubular secretion of aminohippurate, the basis for its use in measuring effective renal plasma flow. Concurrent use would invalidate the test result and raise aminohippurate levels.
What this interaction means in plain words
Aminohippurate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive inhibition of organic anion transporters in the proximal tubule reduces aminohippurate secretion.
What to do
Avoid probenecid before and during renal plasma flow testing with aminohippurate, or interpret results accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aminohippurate and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Aminohippurate with Probenecid?
MediHelp rates the interaction as moderate. Aminohippurate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid blocks the renal tubular secretion of aminohippurate, the basis for its use in measuring effective renal plasma flow. Concurrent use would invalidate the test result and raise aminohippurate levels.
How serious is the interaction between Aminohippurate and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid probenecid before and during renal plasma flow testing with aminohippurate, or interpret results accordingly.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
