Drug interactions
Aminosalicylic acid + Warfarin
Severity: Moderate
Aminosalicylic acid and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminosalicylic acid has been reported to enhance the anticoagulant effect of warfarin, with a possible rise in INR and bleeding. The interaction is not well characterized.
What this interaction means in plain words
Aminosalicylic acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not firmly established; possible interference with vitamin K-dependent clotting factor synthesis.
What to do
Monitor INR closely when starting or stopping aminosalicylic acid and adjust the warfarin dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Aminosalicylic acid with Warfarin?
MediHelp rates the interaction as moderate. Aminosalicylic acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminosalicylic acid has been reported to enhance the anticoagulant effect of warfarin, with a possible rise in INR and bleeding. The interaction is not well characterized.
How serious is the interaction between Aminosalicylic acid and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when starting or stopping aminosalicylic acid and adjust the warfarin dose as required.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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