Drug interactions
amiodarone + warfarin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ INR/bleeding risk.
Mechanism of action
CYP2C9/3A4 inhibition.
Clinical management
Empiric warfarin dose reduction; monitor INR frequently.
Drug reference
References
Frequently asked questions
Can I take amiodarone with warfarin?
The interaction is rated: Major. ↑ INR/bleeding risk.
How serious is the interaction between amiodarone and warfarin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between amiodarone and warfarin managed?
Empiric warfarin dose reduction; monitor INR frequently.
Why do amiodarone and warfarin interact?
CYP2C9/3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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