Drug interactions
Amiodarone + Arformoterol
Severity: Moderate
Amiodarone and Arformoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QT prolongation, and amiodarone itself prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Amiodarone and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Arformoterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia potentiating the effect.
What to do
Monitor ECG and serum potassium and magnesium, particularly at initiation. Reassess the need for the combination if QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Amiodarone with Arformoterol?
MediHelp rates the interaction as moderate. Amiodarone and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QT prolongation, and amiodarone itself prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Amiodarone and Arformoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium, particularly at initiation. Reassess the need for the combination if QTc lengthens substantially.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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