Drug interactions
Amiodarone + Betrixaban
Severity: Major
Amiodarone and Betrixaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-gp, which handles betrixaban efflux, and can raise betrixaban concentrations. This increases the risk of bleeding.
What this interaction means in plain words
Amiodarone and Betrixaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
P-gp inhibition by amiodarone reduces betrixaban efflux and clearance, increasing its exposure.
What to do
Reduce betrixaban to the labeled lower dose (80 mg once, then 40 mg daily) when given with a P-gp inhibitor. Monitor for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Betrixaban?
MediHelp rates the interaction as major. Amiodarone and Betrixaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits P-gp, which handles betrixaban efflux, and can raise betrixaban concentrations. This increases the risk of bleeding.
How serious is the interaction between Amiodarone and Betrixaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled lower dose (80 mg once, then 40 mg daily) when given with a P-gp inhibitor. Monitor for signs of bleeding.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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