Drug interactions
Amiodarone + Buprenorphine buccal
Severity: Moderate
Amiodarone and Buprenorphine buccal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, particularly at higher doses, and amiodarone adds to this effect. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Amiodarone and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes, especially at higher buprenorphine doses or with other risk factors. Consider alternatives if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Buprenorphine buccal?
MediHelp rates the interaction as moderate. Amiodarone and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval, particularly at higher doses, and amiodarone adds to this effect. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Amiodarone and Buprenorphine buccal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, especially at higher buprenorphine doses or with other risk factors. Consider alternatives if QT prolongation develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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