Drug interactions
Amiodarone + Buprenorphine long-acting
Severity: Moderate
Amiodarone and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, and amiodarone adds to this effect. Long-acting injectable formulations sustain exposure, so any effect persists between doses.
What this interaction means in plain words
Amiodarone and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Reassess the need for both drugs if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Amiodarone and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval, and amiodarone adds to this effect. Long-acting injectable formulations sustain exposure, so any effect persists between doses.
How serious is the interaction between Amiodarone and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Reassess the need for both drugs if QT prolongation develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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