Drug interactions
Amiodarone + Butalbital
Severity: Moderate
Amiodarone and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and lower amiodarone concentrations. Reduced antiarrhythmic effect is possible with regular use.
What this interaction means in plain words
Amiodarone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces hepatic CYP3A4, increasing amiodarone clearance.
What to do
Monitor heart rhythm and clinical response during regular butalbital use. Increase amiodarone monitoring if butalbital is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Butalbital?
MediHelp rates the interaction as moderate. Amiodarone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and lower amiodarone concentrations. Reduced antiarrhythmic effect is possible with regular use.
How serious is the interaction between Amiodarone and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and clinical response during regular butalbital use. Increase amiodarone monitoring if butalbital is started or stopped.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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