Drug interactions
Amiodarone + Captopril
Severity: Moderate
Amiodarone and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone has vasodilating and negative chronotropic effects, so combined use with captopril can lower blood pressure further. The effect is generally modest but may be important in patients with heart failure or low volume status.
What this interaction means in plain words
Amiodarone and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Captopril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from ACE inhibition and amiodarone vasodilation and negative chronotropy.
What to do
Monitor blood pressure and heart rate, particularly when starting or intravenously loading amiodarone. Reduce the captopril dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Captopril?
MediHelp rates the interaction as moderate. Amiodarone and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone has vasodilating and negative chronotropic effects, so combined use with captopril can lower blood pressure further. The effect is generally modest but may be important in patients with heart failure or low volume status.
How serious is the interaction between Amiodarone and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly when starting or intravenously loading amiodarone. Reduce the captopril dose if symptomatic hypotension develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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