Drug interactions
Amiodarone + Cenobamate
Severity: Moderate
Amiodarone and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and inhibits CYP2C19, so amiodarone exposure may change unpredictably. Reduced amiodarone effect or toxicity are both possible, and cenobamate itself shortens the QT interval and can cause somnolence and dizziness.
What this interaction means in plain words
Amiodarone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 induction and CYP2C19 inhibition by cenobamate altering amiodarone metabolism.
What to do
Monitor ECG, heart rate and arrhythmia control, and consider checking thyroid and liver function. Adjust the amiodarone dose to clinical response when cenobamate is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Amiodarone with Cenobamate?
MediHelp rates the interaction as moderate. Amiodarone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and inhibits CYP2C19, so amiodarone exposure may change unpredictably. Reduced amiodarone effect or toxicity are both possible, and cenobamate itself shortens the QT interval and can cause somnolence and dizziness.
How serious is the interaction between Amiodarone and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and arrhythmia control, and consider checking thyroid and liver function. Adjust the amiodarone dose to clinical response when cenobamate is started or stopped.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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