Drug interactions
Amiodarone + Conivaptan
Severity: Moderate
Amiodarone and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may increase amiodarone concentrations. Higher levels could add to bradycardia and QT prolongation, and rapid sodium correction with conivaptan adds a risk of electrolyte disturbance.
What this interaction means in plain words
Amiodarone and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing amiodarone clearance.
What to do
Monitor ECG, heart rate and serum sodium and potassium during the short conivaptan course. Reduce or stop amiodarone if QT prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Conivaptan?
MediHelp rates the interaction as moderate. Amiodarone and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may increase amiodarone concentrations. Higher levels could add to bradycardia and QT prolongation, and rapid sodium correction with conivaptan adds a risk of electrolyte disturbance.
How serious is the interaction between Amiodarone and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and serum sodium and potassium during the short conivaptan course. Reduce or stop amiodarone if QT prolongation occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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