Drug interactions
Amiodarone + Cortisone
Severity: Minor
Amiodarone and Cortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may induce CYP3A4 and lower amiodarone levels slightly, while amiodarone may modestly raise corticosteroid exposure. Corticosteroid-induced hypokalemia can also increase the risk of QT-related arrhythmias with amiodarone.
What this interaction means in plain words
Amiodarone and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction and P-gp inhibition, plus corticosteroid-related potassium loss.
What to do
Monitor serum potassium and ECG during prolonged systemic corticosteroid therapy. No empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Cortisone?
MediHelp rates the interaction as minor. Amiodarone and Cortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may induce CYP3A4 and lower amiodarone levels slightly, while amiodarone may modestly raise corticosteroid exposure. Corticosteroid-induced hypokalemia can also increase the risk of QT-related arrhythmias with amiodarone.
How serious is the interaction between Amiodarone and Cortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during prolonged systemic corticosteroid therapy. No empirical dose change is needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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